Laboratoire Sciences, Bioanalytiques et Miniaturisation : Search for orthogonal mechanisms for multidimensional separations

Search for orthogonal mechanisms for multidimensional separations

The detailed characterization of complex samples requires a dramatic increase of the resolution and selectivity of the separation method.

Comprehensive hyphenation of both dimensions
Different retention mechanism in both dimensions.
Thorough studies on the measurement of orthogonally illustrated by experiments in two dimensional comprehensive liquid chromatography (LCxLC)
Innovating developments in the field of data analysis
Application to the separation of phospholipids families by LCxLC (ANR Omégasomes)

GCxGC Chromatogram of an extract of tobacco leaves

Collaborations : Equipe de Statistiques Appliquées de l’ESPCI, ANR Omegasomes

Publications:

Orthogonality measurement, Al Bakain et al., J, Chrom. A, 2011, 1218, 2963-2975
Relationship solutes/orthogonality, Al Bakain et al., J. of Chrom. A, 2012, 1232, 231-241

Capillary electrophoresis (CE) is highly suitable for analysis of various molecules (small inorganic ions, organic compounds such drugs, (...)

– Synthesis of stationary phases in a capillary (by in situ polymerization of monoliths) to develop separation methods in HILIC mode for nanoLC (...)

The laboratory