Laboratoire Sciences, Bioanalytiques et Miniaturisation : Fast Supercritical Fluid Chromatography

Fast Supercritical Fluid Chromatography

Compared to HPLC or UHPLC Supercritical Fluid Chromatography is 3 to 5 times faster:

The separation of n-paraffins having a carbon number between 20 and 60 can be achieved in less than 2 minutes using neat CO₂ with Flame Ionisation Detection
The separation duration is in the same order of magnitude as a second dimension separation in GCxGC ; despite the experimental difficulties, the same level of resolution can be obtained in SFCxSFC

Collaborations : Université de Liège, Université de Zagreb

Publications :

Feasibility of ultra-high performance supercritical carbon dioxide chromatography at conventional pressures, C. Sarazin et al. J. Sep. Sci., 34 (2011) 1773

Feasability of neat carbon dioxide packed column comprehensive two dimensional supercritical fluid chromatography, P. Guibal et al. J. Chromatogr. 1255 (2012) 252-258

Capillary electrophoresis (CE) is highly suitable for analysis of various molecules (small inorganic ions, organic compounds such drugs, (...)

– Synthesis of stationary phases in a capillary (by in situ polymerization of monoliths) to develop separation methods in HILIC mode for nanoLC (...)

The laboratory