Fast Supercritical Fluid Chromatography

Compared to HPLC or UHPLC Supercritical Fluid Chromatography is 3 to 5 times faster:

  • The separation of n-paraffins having a carbon number between 20 and 60 can be achieved in less than 2 minutes using neat CO2 with Flame Ionisation Detection
  • The separation duration is in the same order of magnitude as a second dimension separation in GCxGC ; despite the experimental difficulties, the same level of resolution can be obtained in SFCxSFC

Collaborations : Université de Liège, Université de Zagreb

Publications :

  • Feasibility of ultra-high performance supercritical carbon dioxide chromatography at conventional pressures, C. Sarazin et al. J. Sep. Sci., 34 (2011) 1773
  • Feasability of neat carbon dioxide packed column comprehensive two dimensional supercritical fluid chromatography, P. Guibal et al. J. Chromatogr. 1255 (2012) 252-258


See also...

Search for orthogonal mechanisms for multidimensional separations

The detailed characterization of complex samples requires a dramatic increase of the resolution and selectivity of the separation method. (...) 

> More...

Development in capillary electrophoresis

Capillary electrophoresis (CE) is highly suitable for analysis of various molecules (small inorganic ions, organic compounds such drugs, (...) 

> More...


Practical information

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