Molecularly imprinted polymers

These are based on a polymerization of synthetic polymers that possess cavities specific of a target analyte or a group of structural analogs.
MIPs are obtained by adding a template in a solvent in the presence of a monomer and a cross linker, the monomer being selected for its capacity to strongly interact with the template.

Principle of the synthesis of MIP

One use of MIP
Analysis of LSD in urine with (red) and without (green) using MIP

  • Recent studies:
    • Screening of conditions of synthesis for various organic compounds (pesticides, drugs, toxins…)
    • Production of polymers by radical polymerization and Sol-Gel approach
    • Synthesis of ionic imprinted polymers
    • Miniaturization of the the synthesis of the MIPs

Collaborations: LCPP, ANR Mycodiag, ANR BMAALS, Polyintell, LABERCA, CEA, DIM Analytics

Recent publications:

  • cocaine /metabolites/ biological fluids, V. Thibert et al , J Chromatogr. B, 949–950 (2014) 16– 23
  • explosives / post-blast samples, S. Lordel-Madeleine, et al, Anal Bioanal Chem 405 (2013) 5237-5247
  • nitro musk / environmental waters; M. Lopez-Nogueroles, et al. Talanta 110 (2013) 128-134
  • urinary steroid hormones / abuse in cattle, M. Doué, et al. J. Chromatogr. A, 1270 (2012) 51-61
  • cocaine /benzoylecgonine / hair extract; V. Thibert, et al. Talanta 88 (2012) 412– 419
  • nitroaromatic explosives, S. Lordel, et al. Anal Bioanal Chem 399 (2011) 449-458
  • mycotoxin in cereals, W. Hadj Ali et al.; J. Chromatogr A 1217 (2010) 6668-6673

Highlight : Copresidency of the MIP 2012 international congress, Paris

PhD student: Sara Boulanouar (2014-2017), Manel Moussa (2012-2015)


See also...

Multidimensional separations

Approach widely explored in gas chromatography (GCxGC) Innovating developments in the field of headspace sampling Demonstration of the (...) 

> More...

Solid phase extraction for trace analysis

method based on the distribution of compounds between a stationary phase (selected sorbent) and a liquid phase (sample)Principe de l’extraction (...) 

> More...


Practical information

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