Molecularly imprinted polymers

These are based on a polymerization of synthetic polymers that possess cavities specific of a target analyte or a group of structural analogs.
MIPs are obtained by adding a template in a solvent in the presence of a monomer and a cross linker, the monomer being selected for its capacity to strongly interact with the template.

Principle of the synthesis of MIP

One use of MIP
Analysis of LSD in urine with (red) and without (green) using MIP

  • Recent studies:
    • Screening of conditions of synthesis for various organic compounds (pesticides, drugs, toxins…)
    • Production of polymers by radical polymerization and Sol-Gel approach
    • Synthesis of ionic imprinted polymers
    • Miniaturization of the the synthesis of the MIPs

Collaborations: LCPP, ANR Mycodiag, ANR BMAALS, Polyintell, LABERCA, CEA, DIM Analytics

Recent publications:

  • cocaine /metabolites/ biological fluids, V. Thibert et al , J Chromatogr. B, 949–950 (2014) 16– 23
  • explosives / post-blast samples, S. Lordel-Madeleine, et al, Anal Bioanal Chem 405 (2013) 5237-5247
  • nitro musk / environmental waters; M. Lopez-Nogueroles, et al. Talanta 110 (2013) 128-134
  • urinary steroid hormones / abuse in cattle, M. Doué, et al. J. Chromatogr. A, 1270 (2012) 51-61
  • cocaine /benzoylecgonine / hair extract; V. Thibert, et al. Talanta 88 (2012) 412– 419
  • nitroaromatic explosives, S. Lordel, et al. Anal Bioanal Chem 399 (2011) 449-458
  • mycotoxin in cereals, W. Hadj Ali et al.; J. Chromatogr A 1217 (2010) 6668-6673

Highlight : Copresidency of the MIP 2012 international congress, Paris

PhD student: Sara Boulanouar (2014-2017), Manel Moussa (2012-2015)

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See also...

Oligosorbent

Aptamers = short single-stranded oligonucleotides (DNA or RNA, typically 20-100 base pairs) whose sequence is able to specifically bind (a) (...) 

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Immunosorbents

These are solid sorbent (silica particles, agarose gel, monolith…) covalently grafted by antibodies specific of a molecule or of a group of (...) 

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Practical information

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